Inhibitors of tumor necrosis factor (TNF) are protein-based drugs, often called "biological", which are a pillar of therapy for diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. They work in the treatment of arthritis by blocking a chemical called tumor necrosis factor, which is a major cause of inflammation. There are five currently available TNF inhibitors, 4 administered by subcutaneous injection and one by intravenous injection. They all have similar potential side effects.
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